• OsrsNeedsF2P@lemmy.ml
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    5 days ago

    I take Tylenol whenever I have a headache, but otherwise none. I was on and off a few for a while, but better exercise fixed my various issues better than any pills did.

    I’ll probably pick them back up when exercise isn’t enough, but it’s hard to say how many I’ll be at by then. Maybe 10? I trust the science :P

    • wildbus8979@sh.itjust.works
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      5 days ago

      Tylenol is nearly useless, straight up bad for you, and plain dangerous. If it came out today it wouldn’t be sold over the counter. It’s seriously one of the worst NSAIDS, there’s literally no reason to be using it over Ibuprofen.

      • OsrsNeedsF2P@lemmy.ml
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        5 days ago

        Strong claim is gonna require evidence, since literally every paper I see on the front page of Google search says the opposite. For example, https://pubmed.ncbi.nlm.nih.gov/20236342/, “A randomized, placebo-controlled trial of acetaminophen for treatment of migraine headache”, found “Significantly (P = .001) more patients treated with acetaminophen 1000 mg reported mild to no pain after 2 hours (52.0%) compared with those treated with placebo (32.0%)”

        • wildbus8979@sh.itjust.works
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          5 days ago

          https://www.cochrane.org/news/featured-review-oral-paracetamol-treatment-acute-episodic-tension-type-headache-adults

          The International Headache Society recommends the outcome of being pain-free two hours after taking a medicine as a standard measurement. The outcome of being pain-free or having only mild pain at two hours was reported by 59 in 100 people taking paracetamol 1000 mg, and in 49 out of 100 people taking placebo. This means that only 10 in 100 or 10% of people benefited because of paracetamol 1000 mg.

          Meanwhile the recommended dosage is really really close to the dangerous dosage. Tens of thousands of people a year in the US alone suffer from liver damage or failure because of it.

          https://www.drugwatch.com/drugs/tylenol/

          Findings from one 2022 clinical research trial suggested that regular daily intake of 4 g acetaminophen increased systolic blood pressure in individuals with hypertension by about 5 mm Hg compared with a placebo. The study concluded that this increase in cardiovascular risk calls into question the safety of regular acetaminophen use in similar situations.

          It is the leading cause of acute liver failure in the U.S., and the drug in some cases has led to fatalities. The active ingredient in Tylenol, acetaminophen, accounts for more than 100,000 calls to poison centers, roughly 60,000 emergency-room visits and hundreds of deaths each year in the U.S. In England, it is the leading cause of liver failure requiring transplants.

          This is all pretty well known facts by now.

      • lennybird@lemmy.world
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        5 days ago

        Tylenol (acetaminophen) is not an NSAID.

        Ibuprofen is.

        Ibuprofen particularly can mess up kidneys and stomach lining with chronic use particularly. Meanwhile Tylenol tends to be a bit harder on the liver but is otherwise generally considered safer. This based on my hospital stay as a patient and the doctors veering me away from ibuprofen and toward tylenol, and my wife who is an RN.

        I very much avoid both to the best of my ability but ibuprofen in particular (even though for me it’s WAY more effective), and the only time I’ve really used either with any temporary regularity was with kidney stone, pneumonia, sepsis (all three at same time, mind you), and omicron covid I think it was. Tylenol is generally considered to be safer than Ibuprofen, unless you have preexisting liver issues.